- mercredi 12 septembre 2012
Isoquinoline Derivatives via Stepwise Regioselective sp2 and sp3 C−H Bond Functionalizations
Tarek Boudiar, Zeyneb Sahli, Basker Sundararaju, Mathieu Achard, Zahia Kabouche, Henri Doucet, and Christian Bruneau,
Centre de Recherche en Biotechnologies, BPE 73, Ali Mendjli, Nouvelle Ville, 25000 Constantine, Algeria
Laboratoire d’Obtention de Substances Thérapeutiques (LOST), Département de chimie, Université Mentouri-Constantine, 25000
Constantine, Algeria.
UMR 6226 CNRS, Universitéde Rennes 1, Sciences Chimiques-Catalyse et Organométalliques, Campus de Beaulieu-35042 Rennes
Cedex, France.
ABSTRACT:
Efficient and practically attractive stepwise ruthenium- and palladium-catalyzed regioselective C−H bond functionalizations were achieved to produce 4- substituted tetrahydroisoquinoline derivatives featuring various heteroaromatic substructures in moderate to good yields. Both ruthenium- and palladium-based catalytic processes generated nontoxic and easily separable side products.
